Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | EIF4E | P06730 | 1/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15285968 | 0.89 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15285875 | 0.89 | MKNK1 (0.53) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15288470 | 0.86 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15286317 | 0.86 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15288491 | 0.83 | MKNK1 (0.73) | MKNK1MKNK2CYP3A4EIF4EPIK3CA | |
| SCHEMBL16291395 | 0.81 | MKNK1 (0.73) | MKNK1MKNK2CYP3A4EIF4EPIK3CA | |
| SCHEMBL15288381 | 0.79 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15288199 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL19928564 | 0.78 | MKNK1 (0.39) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL15288215 | 0.78 | MKNK1 (0.53) | MKNK1MKNK2CYP3A4EIF4EEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831079-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2017-08-16 | — | — | EP | disclosed |