Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15285968 | 0.86 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4TGFBR1PKM | |
| SCHEMBL19928565 | 0.80 | MKNK1 (0.49) | MKNK1MKNK2EGLN1ATM | |
| SCHEMBL19243732 | 0.78 | MKNK1 (0.53) | MKNK1MKNK2CYP3A4TGFBR1GAA | |
| SCHEMBL15288381 | 0.77 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4TGFBR1KDM4E | |
| SCHEMBL3850106 | 0.76 | NPC1 (0.53) | TGFBR1PKMKDM4EGLAGAA | |
| SCHEMBL15288134 | 0.75 | GAA (0.48) | CYP3A4TGFBR1PKMKDM4EGLA | |
| SCHEMBL19928566 | 0.74 | FYN (0.45) | MKNK1MKNK2 | |
| SCHEMBL15285875 | 0.73 | MKNK1 (0.53) | MKNK1MKNK2CYP3A4GAAEIF4E | |
| SCHEMBL15288297 | 0.72 | MKNK1 (0.63) | MKNK1MKNK2CYP3A4TGFBR1KDM4E | |
| SCHEMBL3851820 | 0.70 | PIK3CD (0.40) | CYP3A4TGFBR1PKMKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908886-B2 | Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-03-06 | — | — | US | disclosed |