Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.60 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.60 |
| ▸ | NNMT | P40261 | 4/20 | 0.60 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.60 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.60 |
| ▸ | NSD2 | O96028 | 3/20 | 0.60 |
| ▸ | SETD7 | Q8WTS6 | 3/20 | 0.60 |
| ▸ | FASN | P49327 | 3/20 | 0.60 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.60 |
| ▸ | INMT | O95050 | 2/20 | 0.60 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.60 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.60 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.60 |
| ▸ | HNMT | P50135 | 2/20 | 0.60 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.60 |
| ▸ | PNMT | P11086 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | WDR5 | P61964 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6341709 | 0.91 | DOT1L (0.73) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL14174632 | 0.91 | DOT1L (0.73) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL19245155 | 0.85 | DOT1L (0.59) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL27092958 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL27092961 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL19433776 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL18661551 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL95173 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL19433069 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 | |
| SCHEMBL19433014 | 0.84 | DOT1L (0.82) | DOT1LEHMT2NNMTPRMT5CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136194-A1 | CHEMOENZYMATIC SYNTHESIS OF S-NUCLEOSYL AMINO ACIDS (SNA), ANALOGS OF S-ADENOSYL-L-METHIONINE AND S-ADENOSYL-L-HOMOCYSTEINE AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-08-10 | — | — | WO | disclosed |