Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964023 | 0.87 | LCK (0.47) | LCKIRAK4AURKAAURKB | |
| SCHEMBL1964021 | 0.87 | LCK (0.47) | LCKIRAK4AURKAAURKB | |
| Benzimidazole SCHEMBL1924578 | 0.80 | IRAK4 (0.42) | LCKIRAK4AURKAAURKBMAPK10 | |
| SCHEMBL14514057 | 0.78 | IRAK4 (0.58) | LCKIRAK4AURKAAURKBMKNK1 | |
| SCHEMBL1964409 | 0.74 | USP30 (0.38) | — | |
| SCHEMBL10239068 | 0.74 | USP30 (0.38) | — | |
| SCHEMBL376272 | 0.73 | IRAK4 (0.58) | IRAK4AURKAAURKBMAPK10MKNK1 | |
| SCHEMBL12584014 | 0.73 | IRAK4 (0.58) | IRAK4AURKAAURKBMAPK10MKNK1 | |
| SCHEMBL376401 | 0.73 | PIK3CD (0.46) | IRAK4 | |
| SCHEMBL376431 | 0.73 | PIK3CD (0.44) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | Pfizer Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |