Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.65 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.65 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CD69 | Q07108 | 1/20 | 0.48 |
| ▸ | BMP2 | P12643 | 1/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.45 |
| ▸ | SHH | Q15465 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875721 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL9403699 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL7722124 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL7722131 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL15334244 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL18972761 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL25480942 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL7718406 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL7715068 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 | |
| SCHEMBL7715066 | 1.00 | MAPK1 (1.00) | MAPK1LGALS8LGALS3LGALS4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240209369-A1 | COMPLEMENT COMPONENT C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF | BANK OF AMERICA, N.A. | 2024-06-27 | — | — | US | disclosed |
| US-20230151365-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-18 | — | — | US | disclosed |
| US-20210024923-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | US | disclosed |
| US-10844379-B2 | Conjugated antisense compounds and their use | IONIS PHARMACEUTICALS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| EP-2780353-B1 | RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES | ALNYLAM PHARMACEUTICALS INC (US) | 2017-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024923-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | TTR, GALNT1, GALNT3 | MAPK1 4758/4885LGALS8 54/4885LGALS3 48/4885 |
| US-20230151365-A1 | COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION | TTR, GALNT1, GALNT3 | MAPK1 4758/4885LGALS8 54/4885LGALS3 48/4885 |
| US-10844379-B2 | Conjugated antisense compounds and their use | CSGALNACT1, GALNT1, GALNT6 | MAPK1 3983/4885LGALS8 23/4885LGALS3 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.