Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 13/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 13/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1924036 | 0.90 | NTRK1 (0.57) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1924527 | 0.82 | NTRK1 (0.56) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1924646 | 0.80 | NTRK1 (0.73) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL12537487 | 0.79 | NTRK2 (0.55) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1926391 | 0.78 | AURKB (0.55) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1925959 | 0.76 | NTRK1 (0.50) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL14537338 | 0.75 | NTRK1 (0.56) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1924584 | 0.69 | NTRK1 (0.62) | KCNJ6KCNJ3NTRK1KCNJ5NTRK2 | |
| SCHEMBL1924023 | 0.69 | NTRK1 (0.57) | KCNJ6KCNJ3NTRK1NTRK2PIK3CD | |
| SCHEMBL4718624 | 0.67 | KCNJ6 (0.51) | KCNJ6KCNJ3KCNJ5BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |