Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.42 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978760 | 0.90 | NTRK1 (0.72) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL14537179 | 0.88 | NTRK2 (0.56) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL14537181 | 0.85 | AURKB (0.51) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL1924036 | 0.85 | NTRK1 (0.57) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL4710759 | 0.78 | NTRK1 (0.52) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL1924527 | 0.76 | NTRK1 (0.56) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL1924932 | 0.76 | NTRK1 (0.72) | NTRK1NTRK2ERBB4EGFRERBB2 | |
| SCHEMBL5597878 | 0.76 | MEN1 (0.53) | MAPK1 | |
| SCHEMBL1924683 | 0.75 | KCNJ6 (0.49) | NTRK1NTRK2KCNJ6KCNJ3PIK3CD | |
| SCHEMBL1924646 | 0.75 | NTRK1 (0.73) | NTRK1NTRK2ERBB4EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007061882-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |