SCHEMBL192480

SCHEMBL192480

CCOC(=O)c1cc2ccc(C(=O)OC)cc2s1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.68
USP10 Q14694 1/20 0.51
SMN1; SMN2 Q16637 10/20 0.49
NPC1 O15118 8/20 0.49
RAB9A P51151 8/20 0.49
MAPT P10636 3/20 0.49
GAA P10253 2/20 0.49
STAT1 P42224 1/20 0.49
PTPN2 P17706 2/20 0.47
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 3/20 0.46
HPGD P15428 3/20 0.46
ALPL P05186 1/20 0.46
TP53 P04637 1/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
HSD17B10 Q99714 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.44
HDAC3 O15379 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8236909 0.89 HDAC1 (0.65) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL9612671 0.89 HDAC1 (0.53) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL1886145 0.88 HDAC1 (0.80) HDAC1SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL3566902 0.88 HDAC1 (0.53) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL191958 0.87 HDAC1 (0.51) HDAC1SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL3503346 0.87 HDAC1 (0.51) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL3561434 0.85 HDAC1 (0.49) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL1886911 0.84 HDAC1 (0.78) HDAC1SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL3501916 0.83 HDAC1 (0.48) HDAC1USP10SMN1; SMN2NPC1RAB9A
SCHEMBL4605795 0.83 HDAC1 (0.48) HDAC1USP10SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103044390-B Manufacturing method of active layer of ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2015-02-25 CN claimed
CN-103050628-A Method for producing ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2013-04-17 CN claimed
CN-103050629-A Method for producing ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2013-04-17 CN claimed
CN-103044389-A Compound used as active layer of ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2013-04-17 CN claimed
CN-103044390-A Manufacturing method of active layer of ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2013-04-17 CN claimed
CN-102997991-A Ultraviolet detection device LIYANG PRODUCTIVITY PROMOTION CT 2013-03-27 CN claimed
CN-102969450-A Ultraviolet detector LIYANG CITY PRODUCTIVITY PROMOTION CT 2013-03-13 CN claimed
CN-101906093-A Benzo five-membered unsaturated heterocycle compound and preparation method thereof INST OF MEDICINAL BIOTECHNOLOGY OF CHINESE ACADEMY OF MEDICAL SCIENCES 2010-12-08 CN claimed
CN-102969450-B A kind of ultraviolet detector 溧阳市生产力促进中心 2016-06-08 CN disclosed
CN-103050629-B A kind of manufacture method of ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CENTER (CN) 2016-04-06 CN disclosed
CN-102997991-B A kind of ultraviolet detector LIYANG CITY PRODUCTIVITY PROMOTION CENTER (CN) 2016-01-06 CN disclosed
US-9133104-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2015-09-15 US disclosed
CN-103044390-B Manufacturing method of active layer of ultraviolet detector LIYANG PRODUCTIVITY PROMOTION CT 2015-02-25 CN disclosed
US-20140163042-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2014-06-12 US disclosed
WO-2006115835-A2 BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES MERCK & CO., INC. (US) 2006-11-02 WO disclosed
WO-2006115835-A2 BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES MERCK & CO., INC. (US) 2006-11-02 WO disclosed
WO-2006115845-A1 BENZOTHIOPHENE DERIVATIVES MERCK & CO., INC. (US) 2006-11-02 WO disclosed
EP-1677731-A2 THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES Aton Pharma, Inc. (US) 2006-07-12 EP disclosed
WO-2005034880-A2 THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES ATON PHARMA, INC. (US) 2005-04-21 WO disclosed
WO-2005034880-A2 THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES ATON PHARMA, INC. (US) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140163042-A1 ENZYME INHIBITORS HAT1, NR2E1, HDAC3 HDAC1 5/4885USP10 2544/4885SMN1; SMN2 3264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.