Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | USP10 | Q14694 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192480 | 0.89 | HDAC1 (0.68) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1886145 | 0.86 | HDAC1 (0.80) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1886911 | 0.82 | HDAC1 (0.78) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9612674 | 0.80 | HDAC1 (0.76) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15315290 | 0.80 | KDM4E (0.59) | KDM4EPOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1886093 | 0.79 | HDAC1 (1.00) | HDAC1PIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL9612671 | 0.78 | HDAC1 (0.53) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3566902 | 0.78 | HDAC1 (0.53) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8291868 | 0.78 | HDAC1 (0.72) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1886146 | 0.77 | HDAC1 (0.67) | HDAC1KDM4ERAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087129-A2 | FLUORINATED ARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |