Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19335064 | 1.00 | AKR1C1 (0.68) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1061631 | 1.00 | AKR1C1 (0.68) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19335085 | 1.00 | AKR1C1 (0.68) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6349290 | 0.98 | AKR1C1 (0.70) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL248544 | 0.94 | AKR1C1 (0.64) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL844697 | 0.90 | AKR1C1 (0.57) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4810481 | 0.89 | AKR1C1 (0.55) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1041902 | 0.83 | AKR1C1 (0.96) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19249602 | 0.83 | AKR1C1 (0.96) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL66387 | 0.83 | AKR1C1 (0.96) | AKR1C1HDAC4MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115366-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-04-16 | — | — | US | disclosed |
| US-9732080-B2 | Azaindole derivatives as CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115366-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | AKR1C1 1131/4885HDAC4 2932/4885MEN1 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.