Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21431386 | 0.93 | CNR2 (0.34) | NUDT1TLR8TLR7 | |
| SCHEMBL20017163 | 0.93 | NUDT1 (0.33) | NUDT1TLR8PKMTLR7 | |
| SCHEMBL18935611 | 0.93 | NUDT1 (0.37) | NUDT1PIK3R1PIK3CAESR1ESR2 | |
| SCHEMBL19251098 | 0.91 | CNR2 (0.35) | NUDT1TLR8TLR7 | |
| SCHEMBL20243849 | 0.91 | CNR2 (0.35) | NUDT1TLR8TLR7 | |
| SCHEMBL23957925 | 0.91 | NUDT1 (0.34) | NUDT1TLR8PKMTLR7 | |
| SCHEMBL19251245 | 0.89 | CNR2 (0.35) | NUDT1TLR8TLR7 | |
| SCHEMBL22752353 | 0.89 | CNR2 (0.35) | NUDT1TLR8TLR7 | |
| SCHEMBL19245805 | 0.89 | CNR2 (0.35) | NUDT1TLR8TLR7 | |
| SCHEMBL19135671 | 0.85 | NUDT1 (0.35) | NUDT1PIK3R1PIK3CAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993554-B2 | Use of P13K Inhibitors for the Treatment of Obesity, Steatosis and ageing | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2018-06-12 | — | — | US | disclosed |
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |