Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.38 |
| ▸ | CNR1 | P21554 | 8/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22752547 | 0.93 | CNR2 (0.45) | CNR2CNR1SCN5ASCN9A | |
| SCHEMBL19251107 | 0.89 | CHRNB2 (0.35) | CNR2CNR1CYP19A1CHRNB2CHRNA4 | |
| SCHEMBL22752535 | 0.83 | TLR8 (0.33) | TLR8CYP19A1CHRNB2CHRNA4SCN5A | |
| SCHEMBL19558165 | 0.82 | CYP19A1 (0.41) | CYP19A1CHRNB2CHRNA4 | |
| SCHEMBL19139344 | 0.79 | CNR2 (0.38) | CNR2CNR1TLR8 | |
| SCHEMBL18856535 | 0.79 | SCN5A (0.35) | CNR2CNR1TLR8CYP19A1SCN5A | |
| SCHEMBL19139244 | 0.77 | CNR2 (0.40) | CNR2CNR1CHRNB2CHRNA4 | |
| SCHEMBL21902013 | 0.77 | CYP19A1 (0.35) | CYP19A1CHRNB2CHRNA4 | |
| SCHEMBL19232176 | 0.76 | CNR2 (0.39) | CNR2CNR1CYP19A1 | |
| SCHEMBL12812009 | 0.76 | CNR2 (0.36) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |