Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
| ▸ | GUSB | P08236 | 2/20 | 0.30 |
| ▸ | EBP | Q15125 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19663438 | 1.00 | SPHK1 (0.33) | SPHK1DNM1GUSBEBPSIGMAR1 | |
| SCHEMBL21227093 | 1.00 | SPHK1 (0.33) | SPHK1DNM1GUSBEBPSIGMAR1 | |
| SCHEMBL22085914 | 0.84 | SPHK1 (0.31) | SPHK1 | |
| SCHEMBL18583670 | 0.83 | SPHK1 (0.37) | SPHK1 | |
| SCHEMBL19491909 | 0.83 | SPHK1 (0.37) | SPHK1 | |
| SCHEMBL20205239 | 0.83 | SPHK1 (0.37) | SPHK1 | |
| SCHEMBL21940826 | 0.81 | SPHK1 (0.36) | SPHK1 | |
| SCHEMBL21214491 | 0.79 | — | — | |
| SCHEMBL21291133 | 0.78 | SPHK1 (0.33) | SPHK1 | |
| SCHEMBL25144126 | 0.78 | GUSB (0.32) | GUSBEBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | InventisBio Co., Ltd. (CN) | 2021-08-17 | — | — | US | disclosed |
| US-11059819-B2 | Fused hetero-hetero bicyclic compounds and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2021-07-01 | — | — | US | disclosed |
| US-20190345158-A1 | FUSED HETERO-HETERO BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2019-11-14 | — | — | US | disclosed |
| US-9878987-B2 | HSP70 modulators and methods for making and using the same | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091481-B2 | Heterocyclic compounds, preparation and methods and uses thereof | KRAS, NRAS, HRAS | SPHK1 263/4885DNM1 267/4885GUSB 3454/4885 |
| US-11059819-B2 | Fused hetero-hetero bicyclic compounds and methods of use thereof | KRAS, NRAS, HRAS | SPHK1 2146/4885DNM1 212/4885GUSB 1305/4885 |
| US-20210198255-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF | KRAS, NRAS, HRAS | SPHK1 263/4885DNM1 267/4885GUSB 3454/4885 |
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | HSPA2, HSP90AA1, HSP90AB1 | SPHK1 3326/4885DNM1 4778/4885GUSB 3386/4885 |
| US-20190345158-A1 | FUSED HETERO-HETERO BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | SPHK1 2146/4885DNM1 212/4885GUSB 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.