HSPA2

Heat shock-related 70 kDa protein 2 · P54652 · HSPA2 on Sugi Atlas →

1,067 patent compounds predicted against HSPA2, 641 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL23804612 SCHEMBL23804612 1.00 6/20
SCHEMBL23804614 SCHEMBL23804614 1.00 6/20
SCHEMBL23804616 SCHEMBL23804616 1.00 6/20
SCHEMBL23818759 SCHEMBL23818759 0.63 6/20
SCHEMBL23804620 SCHEMBL23804620 1.00 5/20
SCHEMBL23804624 SCHEMBL23804624 1.00 5/20
SCHEMBL23804600 SCHEMBL23804600 0.76 5/20
SCHEMBL23804603 SCHEMBL23804603 0.76 5/20
SCHEMBL23804622 SCHEMBL23804622 0.70 5/20
SCHEMBL23804625 SCHEMBL23804625 0.70 5/20
SCHEMBL23818768 SCHEMBL23818768 0.53 5/20
SCHEMBL23818767 SCHEMBL23818767 0.53 5/20
SCHEMBL23804617 SCHEMBL23804617 1.00 4/20
SCHEMBL23804618 SCHEMBL23804618 1.00 4/20
SCHEMBL23818887 SCHEMBL23818887 1.00 4/20
SCHEMBL23818889 SCHEMBL23818889 1.00 4/20
SCHEMBL23804606 SCHEMBL23804606 0.78 4/20
SCHEMBL23804607 SCHEMBL23804607 0.74 4/20
SCHEMBL23804615 SCHEMBL23804615 0.74 4/20
SCHEMBL23804623 SCHEMBL23804623 0.72 4/20

Clinical trials — most relevant to HSPA2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Study of Heat Shock Protein-Peptide Complex (HSPPC-96) Versus IL-2/DTIC for Stage IV Melanoma PHASE3COMPLETED
OGX-427 in Castration Resistant Prostate Cancer Patients PHASE2COMPLETED
17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease PHASE2COMPLETED
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer PHASE2COMPLETED
Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery PHASE2COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas PHASE1COMPLETED
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery PHASE1COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma PHASE1COMPLETED
Safety and Pharmacology of SNX-5422 Plus Everolimus in Subjects With Neuroendocrine Tumors PHASE1COMPLETED
Vaccine Therapy in Treating Patients With Stage I or Stage II Pancreatic Cancer PHASE1COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer nanUNKNOWN
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease nanCOMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Chronic Heat Therapy for Improving Vascular Health nanCOMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept nanUNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions nanWITHDRAWN
Chronic Passive Heating in Healthy Older Adults nanCOMPLETED
Heat Shock Protein (HSP) 70 to Quantify and Characterize Circulating Tumor Cells nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HSPA2 binder may also engage these)

ProteinNameSimilarity
P34933 1.000 P34933 →
Q9TUG3 1.000 Q9TUG3 →
P17156 1.000 P17156 →
P63017 1.000 P63017 →
Q71U34 1.000 Q71U34 →
A2Q0Z1 1.000 A2Q0Z1 →
P19378 1.000 P19378 →
Q6S4N2 1.000 Q6S4N2 →
P14659 1.000 P14659 →
Q5NVM9 1.000 Q5NVM9 →
P19120 1.000 P19120 →
P08418 1.000 P08418 →
Q61696 1.000 Q61696 →
Q9VG58 1.000 Q9VG58 →
P0DMW0 1.000 P0DMW0 →
P0DMW1 1.000 P0DMW1 →
Q01233 1.000 Q01233 →
P26413 1.000 P26413 →
P08106 1.000 P08106 →
Q4U0F3 1.000 Q4U0F3 →
Q27965 1.000 Q27965 →
Q9BIS2 1.000 Q9BIS2 →
P87047 1.000 P87047 →
Q5R7D3 1.000 Q5R7D3 →
O73885 1.000 O73885 →
P10591 1.000 P10591 →
Q90473 1.000 Q90473 →
P41753 1.000 P41753 →
P22954 1.000 P22954 →
Q8INI8 1.000 Q8INI8 →