Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251002 | 0.83 | GRM5 (0.37) | GRM5MAP4K4PDE4A | |
| SCHEMBL18744472 | 0.79 | CNR2 (0.33) | CNR2 | |
| SCHEMBL18935596 | 0.78 | NUDT1 (0.37) | CNR2 | |
| SCHEMBL20878357 | 0.78 | ESR1 (0.32) | CNR2 | |
| SCHEMBL19069003 | 0.78 | CNR2 (0.31) | CNR2 | |
| SCHEMBL22752536 | 0.77 | CNR2 (0.33) | GRM5CNR2 | |
| SCHEMBL10202037 | 0.76 | GRM5 (0.41) | GRM5MAP4K4PDE4A | |
| SCHEMBL23772094 | 0.75 | PLK1 (0.34) | — | |
| SCHEMBL22752323 | 0.74 | CNR2 (0.33) | CNR2 | |
| SCHEMBL19251175 | 0.74 | CNR1 (0.33) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993554-B2 | Use of P13K Inhibitors for the Treatment of Obesity, Steatosis and ageing | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2018-06-12 | — | — | US | disclosed |
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |