Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 13/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19251612 | 0.88 | PIK3CD (0.38) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19252622 | 0.88 | PIK3CD (0.38) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19251396 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19251410 | 0.81 | LMNA (0.36) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19252667 | 0.81 | LMNA (0.36) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19251611 | 0.80 | PIK3CD (0.44) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19252623 | 0.80 | PIK3CD (0.44) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19251471 | 0.80 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL19251603 | 0.80 | PIK3CD (0.38) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL19251472 | 0.80 | PIK3CD (0.38) | PIK3CDPIK3R1LMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133655-A1 | BENZOTHIAZINE AND BENZOTHIADIAZINE COMPOUNDS AND PREPARATION AND USE | 浙江大学 | 2017-08-10 | — | — | WO | disclosed |