Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19252593 | 0.89 | KDM4E (0.35) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL22752529 | 0.86 | CNR2 (0.42) | — | |
| SCHEMBL19251007 | 0.84 | MAPT (0.32) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL18744472 | 0.78 | CNR2 (0.33) | — | |
| SCHEMBL22752543 | 0.76 | KDM4E (0.31) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL20878357 | 0.76 | ESR1 (0.32) | — | |
| SCHEMBL19069003 | 0.76 | CNR2 (0.31) | — | |
| SCHEMBL18935596 | 0.76 | NUDT1 (0.37) | KDM4EALDH1A1 | |
| SCHEMBL22752534 | 0.75 | KDM4E (0.34) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL9906409 | 0.74 | MEN1 (0.33) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |