Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771928 | 0.86 | KMT2A (0.34) | KMT2AALDH1A1TSHRLMNAHPGD | |
| SCHEMBL12459158 | 0.80 | KMT2A (0.40) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19252754 | 0.80 | KMT2A (0.33) | KMT2AALDH1A1SLC5A2LMNAHPGD | |
| SCHEMBL19965699 | 0.77 | KMT2A (0.60) | KMT2ATDP1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL21893106 | 0.74 | PTPN1 (0.34) | KMT2ATDP1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL19251241 | 0.74 | NPC1 (0.41) | ALDH1A1MAPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12524482 | 0.72 | PARP1 (0.46) | KMT2ATDP1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14930980 | 0.71 | NPC1 (0.34) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22778727 | 0.71 | NPC1 (0.35) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19251352 | 0.71 | NPC1 (0.32) | TDP1MAPK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |