Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | VNN1 | O95497 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19987504 | 0.87 | KMT2A (0.60) | KMT2AVNN1SIRT6TDP1MAPK1 | |
| SCHEMBL16282575 | 0.85 | KDM4E (0.49) | KMT2ATDP1MAPK1ALDH1A1MEN1 | |
| SCHEMBL2678960 | 0.82 | KMT2A (0.68) | KMT2ASIRT6MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30435122 | 0.81 | KMT2A (0.66) | KMT2AVNN1SIRT6MAPK1NAMPT | |
| SCHEMBL6471125 | 0.81 | KMT2A (0.66) | KMT2AVNN1SIRT6MAPK1NAMPT | |
| SCHEMBL19135681 | 0.81 | USP7 (0.41) | KMT2ATDP1ALDH1A1NPC1RAB9A | |
| SCHEMBL2677722 | 0.79 | KMT2A (0.74) | KMT2AVNN1SIRT6MAPK1SMN1; SMN2 | |
| SCHEMBL19252759 | 0.77 | KMT2A (0.36) | KMT2ATDP1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5132154 | 0.77 | KMT2A (0.53) | KMT2ASIRT6TDP1ALDH1A1MEN1 | |
| SCHEMBL1996711 | 0.75 | KMT2A (1.00) | KMT2AVNN1SIRT6MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | KMT2A 400/4885VNN1 1727/4885SIRT6 1044/4885 |
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | KMT2A 400/4885VNN1 1727/4885SIRT6 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.