Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | HPGD | P15428 | 3/20 | 0.81 |
| ▸ | GLA | P06280 | 2/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.73 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.73 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300825 | 0.93 | KDM4E (0.82) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL291560 | 0.92 | KDM4E (0.81) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL19207435 | 0.92 | KDM4E (0.80) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL300924 | 0.91 | KDM4E (0.80) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL296461 | 0.90 | KDM4E (0.81) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL301283 | 0.90 | KDM4E (0.81) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL19254094 | 0.90 | KDM4E (0.78) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL301183 | 0.90 | KDM4E (0.86) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL297560 | 0.90 | KDM4E (0.86) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL300856 | 0.89 | KDM4E (0.76) | KDM4EALDH1A1HPGDGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10765681-B2 | Purine compounds possessing anticancer activity | ACADEMIA SINICA (TW) | 2020-09-08 | — | — | US | disclosed |
| WO-2017136689-A1 | PURINE COMPOUNDS POSSESSING ANTICANCER ACTIVITY | ACADEMIA SINICA (TW) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10765681-B2 | Purine compounds possessing anticancer activity | NTPCR, PNP, NUDT1 | KDM4E 3979/4885ALDH1A1 247/4885HPGD 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.