Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 18/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | LOX | P28300 | 2/20 | 0.31 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.31 |
| ▸ | LOXL1 | Q08397 | 2/20 | 0.31 |
| ▸ | LOXL4 | Q96JB6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19254820 | 0.87 | LOXL2 (0.44) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255417 | 0.85 | LOXL2 (0.54) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20713705 | 0.81 | LOXL2 (0.46) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL28556728 | 0.81 | LOXL2 (0.46) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255418 | 0.78 | LOXL2 (0.53) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19868648 | 0.77 | LOXL2 (0.39) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255103 | 0.76 | LOXL2 (0.40) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20699563 | 0.76 | LOXL2 (0.48) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20699567 | 0.76 | LOXL2 (0.48) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255237 | 0.75 | LOXL2 (0.49) | LOXL2DAOAOC3LOXLOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136870-A9 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136870-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |