Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23812897 | 0.85 | POLB (0.46) | GAAPOLBGFERL3MBTL1P2RX3 | |
| SCHEMBL1099448 | 0.83 | GAA (0.55) | GAAMGAMSIMGAM2KDM4E | |
| SCHEMBL30350284 | 0.80 | GAA (0.64) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL23202774 | 0.80 | GAA (0.64) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL16932995 | 0.77 | PTK2 (0.37) | GAAALDH1A1 | |
| SCHEMBL24456201 | 0.75 | GAA (0.48) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL7278938 | 0.75 | MGAM (0.53) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL29532421 | 0.74 | NPC1 (0.56) | GAAKDM4EPOLBMAPTNPC1 | |
| SCHEMBL209984 | 0.74 | NPC1 (0.56) | GAAKDM4EPOLBMAPTNPC1 | |
| SCHEMBL29631745 | 0.72 | GAA (0.58) | GAAPOLBGFERMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205650-A1 | EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2017-08-16 | — | — | EP | disclosed |