Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 13/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658944 | 1.00 | RIPK1 (0.45) | RIPK1TP53PIK3CDMAPTHPGD | |
| SCHEMBL18366165 | 0.83 | RIPK1 (0.44) | RIPK1TP53 | |
| SCHEMBL25556477 | 0.83 | RIPK1 (0.33) | RIPK1PIK3CDMAPTHPGD | |
| SCHEMBL18365786 | 0.83 | RIPK1 (0.44) | RIPK1TP53MAPT | |
| SCHEMBL18366557 | 0.83 | RIPK1 (0.44) | RIPK1TP53MAPT | |
| SCHEMBL18366558 | 0.83 | RIPK1 (0.44) | RIPK1TP53MAPT | |
| SCHEMBL19658693 | 0.83 | RIPK1 (0.33) | RIPK1PIK3CDMAPTHPGD | |
| SCHEMBL19658983 | 0.82 | RIPK1 (0.45) | RIPK1PIK3CDMAPTHPGD | |
| SCHEMBL19659265 | 0.81 | RIPK1 (0.53) | RIPK1TP53 | |
| SCHEMBL19659041 | 0.80 | RIPK1 (0.46) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |