Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201470 | 0.80 | EGLN1 (0.55) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL3135183 | 0.80 | GAA (0.50) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL9150632 | 0.80 | GAA (0.50) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL26007510 | 0.78 | GAA (0.49) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL23988162 | 0.77 | EGLN1 (0.52) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL10893317 | 0.77 | GAA (0.47) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL8344696 | 0.77 | GAA (0.47) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL26105149 | 0.76 | GAA (0.45) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL15659309 | 0.75 | GAA (0.46) | GAATDP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL18018774 | 0.75 | GAA (0.46) | GAATDP1KDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |