Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | PYGM | P11217 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19255053 | 1.00 | RIPK1 (0.50) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL29415660 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19228225 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL20050205 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19207646 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19207698 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19228222 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19207683 | 0.90 | RIPK1 (0.48) | RIPK1NR1I2CYP2C9PYGLPYGM | |
| SCHEMBL19255319 | 0.87 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL19255504 | 0.87 | RIPK1 (0.46) | RIPK1NR1I2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |