Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 17/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29415671 | 0.80 | RIPK1 (0.45) | RIPK1MTNR1AHTR2AHTR2CHTR2B | |
| SCHEMBL19224616 | 0.80 | RIPK1 (0.45) | RIPK1MTNR1AHTR2AHTR2CHTR2B | |
| SCHEMBL19224615 | 0.80 | RIPK1 (0.45) | RIPK1MTNR1AHTR2AHTR2CHTR2B | |
| SCHEMBL19224595 | 0.80 | RIPK1 (0.45) | RIPK1MTNR1AHTR2AHTR2CHTR2B | |
| SCHEMBL29415730 | 0.80 | RIPK1 (0.45) | RIPK1MTNR1AHTR2AHTR2CHTR2B | |
| SCHEMBL19255560 | 0.78 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL19228442 | 0.77 | RIPK1 (0.63) | RIPK1 | |
| SCHEMBL19207917 | 0.76 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19207687 | 0.76 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19207603 | 0.76 | RIPK1 (0.73) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |