SCHEMBL192555

SCHEMBL192555

COC(=O)c1c[c]c(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA12 O43570 2/20 0.48
CA7 P43166 2/20 0.48
CA9 Q16790 2/20 0.48
CA14 Q9ULX7 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
TSHR P16473 1/20 0.45
MAPT P10636 5/20 0.44
ALDH1A1 P00352 4/20 0.44
XDH P47989 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
MAPK1 P28482 2/20 0.42
KDM4E B2RXH2 3/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
GLA P06280 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26129103 0.80 CA12 (0.53) CA1CA2CA12CA7CA9
SCHEMBL510597 0.80 CA1 (0.53) CA1CA2CA12CA7CA9
SCHEMBL6197887 0.80 CA1 (0.57) CA1CA2CA12CA7CA9
SCHEMBL3062615 0.78 CA1 (0.50) CA1CA2CA12CA7CA9
SCHEMBL1459630 0.78 TDP1 (0.55) CA1CA2CA12CA7CA9
SCHEMBL1206442 0.78 MAPT (0.40) TDP1MAPTALDH1A1MEN1KMT2A
SCHEMBL235433 0.77 HDAC8 (0.48) CA2TSHRALDH1A1HPGDHTT
SCHEMBL7287970 0.77 MAPT (0.49) CA1CA2CA12CA7CA9
SCHEMBL27995848 0.77 CA1 (0.48) CA1CA2CA12CA7CA9
SCHEMBL5109761 0.77 CA1 (0.48) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023186773-A1 SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2023-10-05 WO disclosed
EP-3239137-B1 (5R)-4,5-DIHYDRO-ISOXAZOLE DERIVATIVES AS WELL AS 1-(2-CHLOROACETYL)-4-PIPERIDINE-CARBONITRILE AND -CARBOXAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF E.G. 4-[4-[(5R)-4,5-DIHYDRO-ISOXAZOL-3-YL]-THIAZOL-2-YL]-PIPERIDINE DERIVATIVES AS FUNGICIDES FOR CROP PROTECTION DU PONT (US) 2019-02-13 EP disclosed
US-9920030-B2 Fungicidal azocyclic amides E I DU PONT DE NEMOURS AND COMPANY (US) 2018-03-20 US disclosed
EP-3239137-A1 (5R)-4,5-DIHYDRO-ISOXAZOLE DERIVATIVES AS WELL AS 1-(2-CHLOROACETYL)-4-PIPERIDINE-CARBONITRILE AND -CARBOXAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF E.G. 4-[4-[(5R)-4,5-DIHYDRO-ISOXAZOL-3-YL]-THIAZOL-2-YL]-PIPERIDINE DERIVATIVES AS FUNGICIDES FOR CROP PROTECTION E. I. du Pont de Nemours and Company (US) 2017-11-01 EP disclosed
US-9604962-B2 Fungicidal azocyclic amides E I DU PONT DE NEMOURS AND COMPANY (US) 2017-03-28 US disclosed
US-20150291556-A1 FUNGICIDAL AZOCYCLIC AMIDES CORTEVA AGRISCIENCE LLC 2015-10-15 US disclosed
US-20150291578-A1 FUNGICIDAL AZOCYCLIC AMIDES CORTEVA AGRISCIENCE LLC 2015-10-15 US disclosed
US-9090604-B2 Fungicidal azocyclic amides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-28 US disclosed
EP-2121660-B1 FUNGICIDAL AMIDES DU PONT (US) 2014-12-31 EP disclosed
US-20140081027-A1 FUNGICIDAL AZOCYCLIC AMIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-03-20 US disclosed
US-20090156592-A1 Fungicidal Azocyclic Amides E.I. DU PONT DE NEMOURS AND COMPANY (DE) 2009-06-18 US disclosed
WO-2009055514-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-04-30 WO disclosed
WO-2008091580-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed
US-5051342-A Sharpness, whiteness FUJI PHOTO FILM CO., LTD. (JP) 1991-09-24 US disclosed
US-4880726-A TRANSMITTING LIGHT THROUGH A BAND STOP FILTER; REDUCED COLOR MIXING FUJI PHOTO FILM CO., LTD. (JP) 1989-11-14 US disclosed
US-4853328-A Reagent for assaying hydrogen peroxide and method of quantitative assay for hydrogen peroxide FUJI PHOTO FILM CO., LTD. (JP) 1989-08-01 US disclosed
EP-0284099-A2 Silver halide color photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1988-09-28 EP disclosed
EP-0060518-B2 REAGENT FOR ASSAYING HYDROGEN PEROXIDE AND METHOD OF QUANTITATIVE ASSAY FOR HYDROGEN PEROXIDE FUJI PHOTO FILM CO., LTD. (JP) 1988-09-21 EP disclosed
EP-0060518-B1 REAGENT FOR ASSAYING HYDROGEN PEROXIDE AND METHOD OF QUANTITATIVE ASSAY FOR HYDROGEN PEROXIDE FUJI PHOTO FILM CO., LTD. (JP) 1985-07-17 EP disclosed
EP-0060518-A1 Reagent for assaying hydrogen peroxide and method of quantitative assay for hydrogen peroxide FUJI PHOTO FILM CO., LTD. (JP) 1982-09-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150291556-A1 FUNGICIDAL AZOCYCLIC AMIDES ARG1, NAT1, CHRM1 CA1 1369/4885CA2 603/4885CA12 1795/4885
US-20140081027-A1 FUNGICIDAL AZOCYCLIC AMIDES ARG1, NAT1, CHRM1 CA1 1369/4885CA2 603/4885CA12 1795/4885
US-20090156592-A1 Fungicidal Azocyclic Amides ARG1, NAT1, CHRM1 CA1 1369/4885CA2 603/4885CA12 1795/4885
US-20150291578-A1 FUNGICIDAL AZOCYCLIC AMIDES ARG1, NAT1, CHRM1 CA1 1369/4885CA2 603/4885CA12 1795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.