Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19224398 | 1.00 | RIPK1 (0.42) | RIPK1NR1I2CYP2C9PDE9APDE1C | |
| SCHEMBL19207651 | 1.00 | RIPK1 (0.42) | RIPK1NR1I2CYP2C9PDE9APDE1C | |
| SCHEMBL19880641 | 0.93 | RIPK1 (0.42) | RIPK1NR1I2CYP2C9PDE9APDE1C | |
| SCHEMBL20050166 | 0.84 | TYK2 (0.30) | — | |
| SCHEMBL19255745 | 0.80 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL19255757 | 0.80 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL19207711 | 0.80 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL19207654 | 0.80 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL19207637 | 0.76 | NAMPT (0.46) | RIPK1 | |
| SCHEMBL19207639 | 0.76 | NAMPT (0.46) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |