Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 9/20 | 0.62 |
| ▸ | EGFR | P00533 | 8/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790802 | 0.91 | EGFR (0.63) | FLT1EGFRKDRFGFR1TUBB4A | |
| SCHEMBL14777505 | 0.90 | FLT1 (0.77) | FLT1EGFRKDRFGFR1RAF1 | |
| SCHEMBL7127777 | 0.87 | FLT1 (0.77) | FLT1EGFRKDRTUBB4ATUBB | |
| SCHEMBL24066722 | 0.84 | SYK (0.62) | FLT1EGFRKDRFGFR1RAF1 | |
| SCHEMBL31430910 | 0.84 | SYK (0.62) | FLT1EGFRKDRFGFR1RAF1 | |
| SCHEMBL14777006 | 0.84 | EGFR (0.62) | FLT1EGFRKDRFGFR1TUBB4A | |
| SCHEMBL7123651 | 0.84 | FLT1 (0.84) | FLT1EGFRKDRTUBB4ATUBB | |
| SCHEMBL14777017 | 0.84 | FLT1 (0.61) | FLT1EGFRKDRFGFR1RAF1 | |
| SCHEMBL14776758 | 0.83 | EGFR (0.69) | FLT1EGFRKDRFGFR1TUBB4A | |
| SCHEMBL14777419 | 0.83 | FLT1 (0.54) | FLT1EGFRKDRFGFR1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2578590-B1 | ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KOREA INST SCI & TECH (KR) | 2017-08-16 | — | — | EP | disclosed |