Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948309 | 0.88 | SMN1; SMN2 (0.51) | NPC1RAB9AKDM4ETP53HSD17B10 | |
| SCHEMBL17375095 | 0.80 | NPC1 (0.64) | NPC1RAB9AKDM4ETP53HSD17B10 | |
| SCHEMBL858867 | 0.80 | NPC1 (0.67) | NPC1RAB9AKDM4EHSD17B10MEN1 | |
| SCHEMBL23850102 | 0.79 | NPC1 (0.50) | NPC1RAB9AKDM4ETP53HSD17B10 | |
| SCHEMBL31573749 | 0.75 | NPC1 (0.46) | NPC1RAB9AKDM4EHSD17B10MEN1 | |
| SCHEMBL31429362 | 0.75 | NPC1 (0.46) | NPC1RAB9AKDM4EHSD17B10MEN1 | |
| SCHEMBL16445216 | 0.75 | ALDH1A1 (0.43) | NPC1RAB9AKDM4EHSD17B10MEN1 | |
| SCHEMBL24211038 | 0.74 | ALDH1A1 (0.47) | NPC1RAB9AKDM4ETP53HSD17B10 | |
| SCHEMBL19879840 | 0.74 | ALDH1A1 (0.42) | NPC1RAB9AKDM4ETP53HSD17B10 | |
| SCHEMBL4443917 | 0.73 | CNR2 (0.47) | NPC1RAB9AKDM4ETP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414241-B1 | HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2022-05-04 | — | — | EP | disclosed |
| WO-2017139603-A1 | HALO-SUBSTITUTED PIPERIDINES AS OREXIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2017-08-17 | — | — | WO | disclosed |