Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 3/20 | 0.36 |
| ▸ | CDC25B | P30305 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9190067 | 0.81 | PTPN1 (0.46) | PTPN1ACP1CDC25BLMNAHSD17B10 | |
| SCHEMBL22423785 | 0.72 | HDAC4 (0.44) | PTPN1ATM | |
| SCHEMBL15798299 | 0.71 | PTPN1 (0.46) | PTPN1EPHX1ACP1CDC25BMEN1 | |
| SCHEMBL9532715 | 0.69 | PTPN1 (0.47) | PTPN1ACP1CDC25BMEN1KMT2A | |
| SCHEMBL70825 | 0.66 | PTPN1 (0.56) | PTPN1ACP1CDC25BLMNAHSD17B10 | |
| SCHEMBL2803500 | 0.65 | PTPN1 (0.46) | PTPN1ACP1CDC25BLMNAHSD17B10 | |
| SCHEMBL21810871 | 0.65 | PTPN1 (0.50) | PTPN1ACP1CDC25BLMNAHSD17B10 | |
| SCHEMBL8194669 | 0.64 | PTPN1 (0.59) | PTPN1ACP1CDC25BLMNAHSD17B10 | |
| SCHEMBL12529955 | 0.64 | EPHX1 (0.60) | EPHX1MEN1KMT2ALMNA | |
| SCHEMBL10772617 | 0.64 | EPHX1 (0.52) | EPHX1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732085-B2 | Pyridinone and pyrimidinone derivatives as factor Xia | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-08-15 | — | — | US | disclosed |