Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29989046 | 0.85 | HASPIN (0.49) | HASPINRPS6KA5POLBKDM4ENPC1 | |
| SCHEMBL21501930 | 0.85 | HASPIN (0.49) | HASPINRPS6KA5POLBKDM4ENPC1 | |
| SCHEMBL18926933 | 0.80 | HTR2A (0.44) | HASPINHDAC8RECQLROCK1DYRK1A | |
| SCHEMBL29491253 | 0.77 | HTR2A (0.44) | HASPINHDAC8RECQLMKNK2HTR2C | |
| SCHEMBL28667718 | 0.76 | RECQL (0.49) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL13217 | 0.76 | RECQL (0.61) | POLBNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL1717344 | 0.75 | KMO (0.55) | HDAC8POLBKDM4EHPGDHSD17B10 | |
| SCHEMBL29958837 | 0.74 | CDK8 (0.43) | HASPINHDAC8RPS6KA5NPC1TP53 | |
| SCHEMBL256359 | 0.74 | CDK8 (0.43) | HASPINHDAC8RPS6KA5NPC1TP53 | |
| SCHEMBL18939024 | 0.73 | CYP19A1 (0.50) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133657-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |