Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.63 |
| ▸ | KDR | P35968 | 13/20 | 0.62 |
| ▸ | FLT4 | P35916 | 12/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | TEK | Q02763 | 4/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.62 |
| ▸ | AURKA | O14965 | 3/20 | 0.62 |
| ▸ | RAF1 | P04049 | 3/20 | 0.58 |
| ▸ | FLT1 | P17948 | 9/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258107 | 0.91 | KDR (0.73) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL4023679 | 0.87 | SRC (0.66) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL19258108 | 0.87 | KDR (0.63) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL17278101 | 0.87 | SRC (0.66) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL4384142 | 0.86 | BRAF (0.57) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL7211076 | 0.85 | KDR (0.66) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL19258210 | 0.85 | BRAF (0.64) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL5501376 | 0.84 | KDR (0.66) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL4373308 | 0.84 | BRAF (0.55) | BRAFKDRFLT4PDGFRBTEK | |
| SCHEMBL19258207 | 0.84 | RAF1 (0.64) | BRAFKDRFLT4PDGFRBTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |