Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.73 |
| ▸ | FLT4 | P35916 | 10/20 | 0.73 |
| ▸ | AURKA | O14965 | 4/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.73 |
| ▸ | TEK | Q02763 | 4/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.73 |
| ▸ | BRAF | P15056 | 4/20 | 0.60 |
| ▸ | RAF1 | P04049 | 4/20 | 0.60 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | FLT1 | P17948 | 7/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211076 | 0.95 | KDR (0.66) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL19258108 | 0.92 | KDR (0.63) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL19258554 | 0.91 | BRAF (0.63) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL17278101 | 0.90 | SRC (0.66) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL4023679 | 0.90 | SRC (0.66) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL19258210 | 0.89 | BRAF (0.64) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL5501376 | 0.88 | KDR (0.66) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL19258467 | 0.87 | AURKA (0.62) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL19258207 | 0.87 | RAF1 (0.64) | KDRFLT4AURKAPDGFRBTEK | |
| SCHEMBL4377465 | 0.87 | KDR (0.65) | KDRFLT4AURKAPDGFRBTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |