Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PPM1B | O75688 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199077 | 1.00 | POLB (0.57) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL6127597 | 1.00 | POLB (0.57) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL15400698 | 1.00 | POLB (0.57) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL16199396 | 1.00 | POLB (0.57) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL9977663 | 1.00 | POLB (0.57) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL22947121 | 0.92 | POLB (0.68) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL1756841 | 0.92 | POLB (0.68) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL22947120 | 0.92 | POLB (0.68) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL1756845 | 0.92 | POLB (0.68) | POLBAPEX1TDP1PPM1BPTPN1 | |
| SCHEMBL26003315 | 0.92 | POLB (0.68) | POLBAPEX1TDP1PPM1BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133657-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |