Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653398 | 0.82 | MAPT (0.72) | MAPTSMN1; SMN2CYP2C9CYP2C19HSD17B10 | |
| SCHEMBL4002576 | 0.82 | SIRT2 (0.48) | MAPTHSD17B10NPC1SIRT2MEN1 | |
| SCHEMBL19259050 | 0.79 | SMN1; SMN2 (0.53) | MAPTSMN1; SMN2CYP2C9CYP2C19HSD17B10 | |
| SCHEMBL37463 | 0.77 | IDO1 (0.70) | MAPTCYP2C9CYP2C19IDO1AKR1C3 | |
| SCHEMBL4001655 | 0.73 | MAPT (0.64) | MAPTSMN1; SMN2CYP2C9CYP2C19HSD17B10 | |
| SCHEMBL7087223 | 0.71 | IDO1 (0.61) | MAPTHSD17B10IDO1LMNAL3MBTL1 | |
| SCHEMBL19621588 | 0.71 | IDO1 (0.61) | MAPTSMN1; SMN2CYP2C19IDO1LMNA | |
| SCHEMBL11441117 | 0.71 | IDO1 (0.61) | MAPTSMN1; SMN2CYP2C19IDO1LMNA | |
| SCHEMBL21753948 | 0.70 | KCNJ1 (0.60) | MAPTIDO1LMNAL3MBTL1NPC1 | |
| SCHEMBL9347010 | 0.70 | IDO1 (0.59) | MAPTSMN1; SMN2IDO1HTTAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732073-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2017-08-15 | — | — | US | disclosed |