Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PLK1 | P53350 | 10/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.43 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927355 | 0.87 | PLK1 (0.47) | AURKAPLK1PLK3PLK2SGK1 | |
| SCHEMBL1928456 | 0.86 | PLK1 (0.52) | PLK1PLK3PLK2LRRK2USP30 | |
| SCHEMBL1925664 | 0.85 | PLK1 (0.47) | AURKAPLK1PLK3PLK2SGK1 | |
| SCHEMBL1927285 | 0.85 | PLK1 (0.50) | AURKAPLK1PLK3PLK2RPS6KA3 | |
| SCHEMBL1926374 | 0.84 | LRRK2 (0.49) | PLK1PLK3PLK2LRRK2USP30 | |
| SCHEMBL1926244 | 0.84 | PLK1 (0.49) | AURKAPLK1PLK3PLK2RPS6KA3 | |
| SCHEMBL1926562 | 0.83 | USP30 (0.53) | AURKAPLK1PLK3PLK2LRRK2 | |
| SCHEMBL1926343 | 0.83 | USP30 (0.49) | AURKAPLK1PLK3PLK2RPS6KA3 | |
| SCHEMBL1925997 | 0.83 | PLK1 (0.48) | AURKAPLK1PLK3PLK2RPS6KA3 | |
| SCHEMBL1927087 | 0.83 | PLK1 (0.48) | AURKAPLK1PLK3PLK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | claimed |
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | disclosed |
| US-20080015192-A1 | INHIBITORS OF POLO-LIKE KINASES | ABBVIE INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015192-A1 | INHIBITORS OF POLO-LIKE KINASES | PLK1, PLK2, BUB1B | AURKA 16/4885PLK1 1/4885PLK3 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.