Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19278659 | 0.85 | HDAC1 (0.79) | HDAC6HDAC1MEN1KMT2ANPC1 | |
| SCHEMBL31663910 | 0.85 | HDAC1 (0.79) | HDAC6HDAC1MEN1KMT2ANPC1 | |
| SCHEMBL19260245 | 0.84 | HDAC6 (0.71) | HDAC6HDAC1 | |
| SCHEMBL19260282 | 0.78 | HDAC1 (0.73) | HDAC6HDAC1MEN1KMT2ASIRT1 | |
| SCHEMBL8554042 | 0.76 | L3MBTL1 (0.70) | MEN1KMT2ALMNASIRT1ALDH1A1 | |
| SCHEMBL21606311 | 0.75 | GSK3B (0.49) | HDAC6MEN1KMT2ALMNAPTPN1 | |
| SCHEMBL23440090 | 0.74 | PTPN1 (0.69) | MEN1KMT2APTPN1ALDH1A1 | |
| SCHEMBL3908495 | 0.74 | KMT2A (0.53) | HDAC6HDAC1MEN1KMT2ALMNA | |
| SCHEMBL19278555 | 0.73 | HDAC6 (1.00) | HDAC6HDAC1 | |
| SCHEMBL1366022 | 0.73 | HDAC6 (0.64) | HDAC6HDAC1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416633-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | The Board of Trustees of the University of Illinois (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142883-A1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-08-24 | — | — | WO | disclosed |