Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | ABL2 | P42684 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260534 | 0.89 | KIT (0.54) | EHMT2EGFRKITABL1SRC | |
| SCHEMBL19260530 | 0.85 | KIT (0.55) | EHMT2EGFRKITABL1SRC | |
| SCHEMBL19260528 | 0.84 | TLR9 (0.48) | EHMT2NSD2 | |
| Trifluoroacetic Acid SCHEMBL20720749 | 0.83 | KIT (0.47) | EHMT2EGFRKITABL1SRC | |
| Trifluoroacetic Acid SCHEMBL20720740 | 0.80 | KIT (0.49) | EHMT2EGFRKITABL1SRC | |
| SCHEMBL23668017 | 0.80 | KIT (0.53) | EHMT2EGFRKIT | |
| Hydrochloric Acid SCHEMBL19260531 | 0.79 | KIT (0.52) | EHMT2EGFRKIT | |
| Hydrochloric Acid SCHEMBL29565760 | 0.79 | KIT (0.52) | EHMT2EGFRKIT | |
| SCHEMBL19260536 | 0.76 | EHMT2 (0.58) | EHMT2EGFRKITNSD2 | |
| SCHEMBL20720636 | 0.75 | EHMT2 (0.53) | EHMT2EGFRABL1SRCNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416963-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142947-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-08-24 | — | — | WO | disclosed |