Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260675 | 0.78 | HRH3 (0.50) | KCNH2HRH3ADRA1AHTR4KDM4E | |
| Trifluoroacetic Acid SCHEMBL19260825 | 0.74 | HRH3 (0.53) | KCNH2HRH3ADRA1ACACNA1BKDM4E | |
| Trifluoroacetic Acid SCHEMBL20720681 | 0.70 | EHMT2 (0.55) | — | |
| SCHEMBL19260826 | 0.69 | HRH3 (0.51) | KCNH2HRH3ADRA1AKDM4EALDH1A1 | |
| SCHEMBL20720682 | 0.68 | EHMT2 (0.43) | HTR4 | |
| Trifluoroacetic Acid SCHEMBL19260754 | 0.67 | EHMT2 (0.49) | — | |
| SCHEMBL19260636 | 0.66 | HRH3 (0.56) | KCNH2HRH3ADRA1AKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL20720766 | 0.65 | EHMT2 (0.54) | — | |
| Formic Acid SCHEMBL19260676 | 0.64 | KDM4E (0.46) | KCNH2HRH3ADRA1AKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL19260764 | 0.64 | EGFR (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416963-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142947-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-08-24 | — | — | WO | disclosed |