Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19260686 | 0.78 | KCNH2 (0.43) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| SCHEMBL19260636 | 0.74 | HRH3 (0.56) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| Formic Acid SCHEMBL19260676 | 0.73 | KDM4E (0.46) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| SCHEMBL3131412 | 0.72 | MAOB (0.59) | HRH3KDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL19260720 | 0.72 | HRH3 (0.54) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL19260825 | 0.72 | HRH3 (0.53) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3127783 | 0.72 | MAOB (0.58) | HRH3KDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL20720695 | 0.71 | HRH3 (0.47) | HRH3KCNH2ADRA1AACP1 | |
| SCHEMBL19260826 | 0.71 | HRH3 (0.51) | HRH3KCNH2ADRA1AKDM4ESMN1; SMN2 | |
| SCHEMBL28405124 | 0.70 | ACP1 (0.57) | HRH3KCNH2ADRA1AHTR4ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416963-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142947-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-08-24 | — | — | WO | disclosed |