Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.76 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | DAO | P14920 | 1/20 | 0.70 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
| ▸ | LTA4H | P09960 | 2/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.59 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL27807374 | 0.95 | SRD5A2 (0.83) | SRD5A2AKR1C3TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL3021235 | 0.93 | SRD5A2 (0.80) | SRD5A2AKR1C3TSHRDAONAPRT | |
| SCHEMBL1888572 | 0.93 | SRD5A2 (0.88) | SRD5A2AKR1C3TSHRDAONAPRT | |
| SCHEMBL200428 | 0.93 | SRD5A2 (0.88) | SRD5A2AKR1C3TSHRDAONAPRT | |
| Diphenylether SCHEMBL17104399 | 0.93 | SRD5A2 (0.80) | SRD5A2AKR1C3TSHRDAONAPRT | |
| SCHEMBL6892687 | 0.93 | SRD5A2 (0.88) | SRD5A2AKR1C3TSHRDAONAPRT | |
| Diphenylether SCHEMBL12971355 | 0.91 | SRD5A2 (0.66) | SRD5A2AKR1C3TSHRDAONAPRT | |
| Hydrochloric Acid SCHEMBL10520761 | 0.91 | SRD5A2 (0.84) | SRD5A2AKR1C3TSHRDAONAPRT | |
| Ammonia Solution, Strong SCHEMBL18151747 | 0.91 | SRD5A2 (0.84) | SRD5A2AKR1C3TSHRDAONAPRT | |
| SCHEMBL7822422 | 0.87 | SRD5A2 (1.00) | SRD5A2AKR1C3PARP10PARP15PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956149-B1 | Polysiliconated phosphoramide fire retardant | THE BOEING COMPANY (US) | 2011-06-07 | — | — | US | disclosed |
| US-4739115-A | FIREPROOF | MCDONNELL DOUGLAS CORPORATION (US) | 1988-04-19 | — | — | US | disclosed |
| US-4582932-A | FIREPROOFING ADDITIVE | MCDONNELL DOUGLAS CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| US-4403075-A | GLASS FIBER REINFORCEMENT; AIRCRAFT; CONSTRUCTION MATERIALS | MCDONNELL DOUGLAS CORPORATION (US) | 1983-09-06 | — | — | US | disclosed |
| US-4364991-A | RESIN WITH A PHOSPHORYLATED AMIDE | MCDONNELL DOUGLAS CORPORATION (US) | 1982-12-21 | — | — | US | disclosed |
| US-4308197-A | POLYIMIDE OR POLYEPOXIDE AND AN AMMONIUM OR AMINE SALT OF AN ORGANIC PHOSPHONIC OR PHOSPHINIC ACID; CHAR STABILITY; AIRCRAFT | MCDONNELL DOUGLAS CORPORATION (US) | 1981-12-29 | — | — | US | disclosed |
| US-4255483-A | Fire barrier compositions and composites | MCDONNELL DOUGLAS CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |