Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.60 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.60 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.60 |
| ▸ | IDH1 | O75874 | 5/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926851 | 1.00 | PLK1 (0.60) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1926852 | 1.00 | PLK1 (0.60) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1925656 | 0.78 | PLK1 (0.65) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1926504 | 0.78 | PLK1 (0.65) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1925660 | 0.78 | PLK1 (0.65) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1925874 | 0.78 | CCR6 (0.38) | PLK1AURKBAURKA | |
| SCHEMBL27773620 | 0.77 | IDH1 (0.43) | IDH1 | |
| SCHEMBL4378531 | 0.75 | MAPKAPK2 (1.00) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL4366210 | 0.75 | MAPKAPK2 (1.00) | PLK1DAPK3ROCK2CHEK2PIM1 | |
| SCHEMBL1926916 | 0.75 | PLK1 (0.55) | PLK1DAPK3ROCK2CHEK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956185-B2 | Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases | ABBOTT LABORATORIES (US) | 2011-06-07 | — | — | US | disclosed |
| US-20080015192-A1 | INHIBITORS OF POLO-LIKE KINASES | ABBVIE INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015192-A1 | INHIBITORS OF POLO-LIKE KINASES | PLK1, PLK2, BUB1B | PLK1 1/4885DAPK3 299/4885ROCK2 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.