Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 5/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397186 | 1.00 | ADK (0.45) | ADKSLC29A1KMT2APOLBTP53 | |
| SCHEMBL397185 | 1.00 | ADK (0.45) | ADKSLC29A1KMT2APOLBTP53 | |
| SCHEMBL10225976 | 0.87 | ADK (0.47) | ADKRIPK2 | |
| SCHEMBL399455 | 0.87 | ADK (0.47) | ADKRIPK2 | |
| SCHEMBL399456 | 0.87 | ADK (0.47) | ADKRIPK2 | |
| SCHEMBL16236390 | 0.81 | ADK (0.54) | ADKSLC29A1RIPK2 | |
| SCHEMBL29484542 | 0.81 | ADK (0.54) | ADKSLC29A1RIPK2 | |
| Acetic Acid SCHEMBL30180706 | 0.81 | ADK (0.51) | ADKSLC29A1RIPK2 | |
| SCHEMBL19264031 | 0.78 | RIPK2 (0.48) | ADKRIPK2 | |
| SCHEMBL398713 | 0.78 | ADK (0.48) | ADKSLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |