Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325898 | 0.90 | TLR8 (0.57) | TLR8TLR7HPGDMAPK1ALDH1A1 | |
| SCHEMBL20646538 | 0.89 | TLR8 (0.61) | TLR8TLR7HPGDMAPK1 | |
| SCHEMBL10343530 | 0.88 | TLR8 (0.58) | TLR8TLR7HPGDMAPK1ALDH1A1 | |
| SCHEMBL10325171 | 0.87 | TLR8 (0.60) | TLR8TLR7HPGDMAPK1ALDH1A1 | |
| SCHEMBL10325458 | 0.86 | TLR8 (0.66) | TLR8TLR7HPGDMAPK1ABL1 | |
| SCHEMBL10325097 | 0.83 | TLR8 (0.63) | TLR8TLR7HPGDL3MBTL1 | |
| SCHEMBL10325503 | 0.83 | TLR8 (0.56) | TLR8TLR7HPGDMAPK1ABL1 | |
| SCHEMBL10345032 | 0.82 | TLR8 (0.53) | TLR8TLR7HPGDMAPK1ALDH1A1 | |
| SCHEMBL10325919 | 0.82 | TLR8 (0.86) | TLR8TLR7 | |
| SCHEMBL15499091 | 0.81 | TLR8 (0.58) | TLR8TLR7HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3208263-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-3207930-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | VentiRx Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |