Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926552 | 1.00 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL1926556 | 1.00 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL3439787 | 0.78 | ALDH1A1 (0.38) | MAPK1 | |
| SCHEMBL11547511 | 0.77 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL7762970 | 0.77 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL28323339 | 0.77 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL9635126 | 0.74 | MAPK1 (0.36) | MAPK1 | |
| SCHEMBL20017114 | 0.72 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL12155247 | 0.72 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL5074952 | 0.72 | MAPK1 (0.35) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956201-B2 | Reacting glycidyl ether with fluoride salt, then dialkylmalonate, coupling of (S)-4-fluoromethyl-dihydro-furan-2-one formed with amino-pyrido[2,1-a]isoquinoline derivative, cyclization; useful for treatment and/or prophylaxis of diseases associated with DPP IV such as diabetes, inflammatory bowel disease | HOFFMAN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | disclosed |
| EP-2079721-B1 | PROCESS FOR THE PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE | HOFFMANN LA ROCHE (CH) | 2010-07-28 | — | — | EP | disclosed |
| US-20080108816-A1 | PROCESS FOR THE PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108816-A1 | PROCESS FOR THE PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE | DPP4, DPP7, DPP3 | MAPK1 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.