Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3420467 | 0.90 | EGLN3 (0.56) | EGLN3EGLN1 | |
| SCHEMBL3423631 | 0.83 | MEN1 (0.50) | ALDH1A1KDM4ELMNATSHRPKM | |
| SCHEMBL19267278 | 0.81 | EGLN3 (0.46) | EGLN3ALDH1A1KDM4ELMNABRD4 | |
| SCHEMBL19267071 | 0.76 | POLB (0.54) | EGLN3ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL19267144 | 0.75 | RGS4 (0.48) | EGLN3LMNATSHRBRD4TP53 | |
| SCHEMBL3422070 | 0.73 | EGLN3 (0.62) | EGLN3EGLN1 | |
| SCHEMBL19267290 | 0.72 | BRD4 (0.50) | EGLN3PIK3CAALDH1A1KDM4ELMNA | |
| SCHEMBL19267291 | 0.71 | EGLN3 (0.43) | EGLN3KDM4EBRD4EGLN1MEN1 | |
| SCHEMBL3421192 | 0.71 | EGLN3 (0.69) | EGLN3KDM4ELMNAEGLN1HTT | |
| SCHEMBL18134558 | 0.71 | EGLN3 (0.49) | EGLN3KDM4ETRPA1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037922-B9 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-08-23 | — | — | EP | disclosed |