RGS4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13516928	1.00	20/20
SCHEMBL13516931	1.00	20/20
SCHEMBL13517061	1.00	20/20
SCHEMBL13517154	1.00	20/20
SCHEMBL13517231	0.86	20/20
SCHEMBL13516956	0.82	20/20
SCHEMBL13517044	0.81	20/20
SCHEMBL13517152	0.79	20/20
SCHEMBL13516925	0.77	20/20
SCHEMBL13517047	0.74	20/20
SCHEMBL13517115	0.74	20/20
SCHEMBL13516897	0.73	20/20
SCHEMBL13516803	0.71	20/20
SCHEMBL13516834	1.00	19/20
SCHEMBL13516952	1.00	19/20
SCHEMBL13516989	0.89	19/20
SCHEMBL13516707	0.89	19/20
SCHEMBL13516969	0.82	19/20
SCHEMBL13517155	0.81	19/20
SCHEMBL13516859	0.79	19/20

Clinical trials — most relevant to RGS4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Pharmacokinetic Study of Paliperidone ER	PHASE4	UNKNOWN
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.	PHASE4	UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy	PHASE1/PHASE2	WITHDRAWN
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Safety Study of the Effect of Scelectium Tortuosum (as Zembrin®)in Aged Normals	PHASE1	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Inherited Reproductive Disorders	nan	RECRUITING
Study Looking at the Recovery of New Onset Cardiomyopathy	nan	COMPLETED
Imaging and Genetic Investigation of Learning and Decision Making	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RGS4 binder may also engage these)

Protein	Name	Similarity
Q4R525	—	1.000	Q4R525 →
Q5R747	—	1.000	Q5R747 →
Q0R4E4	—	1.000	Q0R4E4 →
P49799	—	1.000	P49799 →
Q29RM9	—	1.000	Q29RM9 →
O08899	—	1.000	O08899 →
Q0P5H5	—	1.000	Q0P5H5 →
Q7SZC6	—	1.000	Q7SZC6 →
Q3S853	—	0.997	Q3S853 →
O15539	—	0.995	O15539 →
Q6DGI0	—	0.994	Q6DGI0 →
RGS8	Regulator of G-protein signaling 8	0.993	landscape →
P49800	—	0.992	P49800 →
Q864Z2	—	0.992	Q864Z2 →
O08850	—	0.992	O08850 →
O08849	—	0.992	O08849 →
P41220	—	0.992	P41220 →
Q9JHX0	—	0.992	Q9JHX0 →
P56700	—	0.991	P56700 →
Q3T0T8	—	0.991	Q3T0T8 →
RGS16	Regulator of G-protein signaling 16	0.991	landscape →
P49804	—	0.986	P49804 →
P97844	—	0.986	P97844 →
Q6RG78	—	0.986	Q6RG78 →
Q95K68	—	0.986	Q95K68 →
O46471	—	0.986	O46471 →
P97428	—	0.985	P97428 →
Q8BXT1	—	0.985	Q8BXT1 →
Q99PG4	—	0.985	Q99PG4 →
Q9QZB0	—	0.984	Q9QZB0 →