Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19268068 | 0.81 | CHRM1 (0.44) | CHRM1PDE2APDE11A | |
| SCHEMBL23672881 | 0.81 | CHRM1 (0.46) | CHRM1PDE2APDE11AGABRA1 | |
| SCHEMBL23672612 | 0.80 | CHRM1 (0.49) | CHRM1PDE2APDE11A | |
| SCHEMBL19268069 | 0.80 | CHRM1 (0.47) | CHRM1PDE2APDE11A | |
| SCHEMBL20031032 | 0.76 | CHRM1 (0.53) | CHRM1PDE2APDE11A | |
| SCHEMBL20030497 | 0.70 | CHRM1 (0.77) | CHRM1PDE2APDE11A | |
| SCHEMBL23672853 | 0.70 | CHRM1 (0.40) | CHRM1PDE2APDE11A | |
| SCHEMBL23672892 | 0.70 | CHRM1 (0.35) | CHRM1PDE2APDE11AGABRA1 | |
| SCHEMBL23672863 | 0.69 | CHRM1 (0.51) | CHRM1PDE2APDE11A | |
| SCHEMBL23672596 | 0.69 | CHRM1 (0.51) | CHRM1PDE2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416639-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | UNIV VANDERBILT (US) | 2022-06-08 | — | — | EP | disclosed |
| WO-2017143041-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2017-08-24 | — | — | WO | disclosed |