Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.86 |
| ▸ | CYCS | P99999 | 4/20 | 0.83 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | TERT | O14746 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709532 | 0.93 | TOP1 (1.00) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL29354037 | 0.93 | TOP1 (1.00) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL16552331 | 0.91 | TOP1 (0.71) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL3047596 | 0.91 | TOP1 (0.97) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL19640853 | 0.91 | CYCS (1.00) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL12842181 | 0.91 | CYCS (0.97) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL31463632 | 0.91 | TOP1 (0.97) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL17183606 | 0.91 | TOP1 (0.97) | TOP1CYCSENPP2ABCG2TERT | |
| SCHEMBL1497141 | 0.91 | TOP1 (0.97) | TOP1CYCSENPP2ABCG2TERT | |
| Hydrochloric Acid SCHEMBL17002623 | 0.91 | TOP1 (0.97) | TOP1CYCSENPP2ABCG2TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170242034-A1 | METHODS FOR IN VITRO INVESTIGATING MITOCHONDRIAL REPLICATION DYSFUNCTION IN A BIOLOGICAL SAMPLE, KITS AND USES THEREOF, THERAPEUTIC METHODS AGAINST PROGEROID-LIKE SYNDROMES OR SYMPTOMES AND SCREENING METHOD FOR IDENTIFYING PARTICULAR PROTEASE INHIBITOR(S) AND/OR NITROSO-REDOX STRESS SCAVENGER COMPOUND(S) | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2017-08-24 | — | — | US | disclosed |